Reprints Available Upon Request

Manuscripts:

Butterworth, B.E., L.L. Aylward, and S.M. Hays.  Accepted.  A mechanism-based cancer risk assessment for 1,4-dichlorobenzene.  Reg. Toxicol. Pharmacol.

Nichols, B.R., K.L. Hentz, L.L. Aylward, S.M. Hays, and J.C. Lamb.  Accepted.  Rapid communication:  Age-specific reference ranges for polychlorinated biphenyls (PCBs) based on the NHANES 2001-2002 survey.  J. Toxicol. Environ. Health.

Hays, S.M., Becker, R., Leung, H.W., Aylward, L.L., and Pyatt, D.W. Biomonitoring equivalents: A screening approach for interpreting biomonitoring results from a public health risk perspective.  Reg. Toxicol. Pharmacol.  47(1):96-109.

Buchanan, S., Pyatt, D.W. and Carpenter, J. 2006 “Freeze-drying Human Hematopoietic Stem and Progenitor Cells Loaded with Trehalose.”  Accepted, Nature Biotechnology.

Pyatt, D.W., Aylward, L., and Hays, S.  Accepted.  Is age an independent risk factor for chemically induced acute myelogenous leukemia in children? Journal of Toxicology and Environmental Health, Part B.

Rowlands, J.C., R.A. Budinsky, L.L. Aylward, A.S. Faqi, and E.W. Carney.  2006.  Sex ratio of the offspring of Sprague-Dawley rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and lactationally in a three-generation study. Toxicol. Appl. Pharmacol. 216(1):29-33.

Cheng, H., L.L. Aylward, T.B. Starr, C. Beall, R. Brunet, G. Carrier, and E. Delzell. 2006.  TCDD exposure-response analysis and risk assessment.  Risk Analysis. 26(4):1059-71.  Risk Analysis. 26(4):1059-71.

Guzelian, P., Quattrochi, L., Karch, N., Aylward, L.L., and Kaley, R.  2006.  Does dioxin exert toxic effects in humans at or near current background body levels?  An evidence-based conclusion.  Hum. Exp.  Toxicol.  25:99-105

Gray, M.N., Aylward, L.L., and Keenan, R.E.  2006.  Relative cancer potencies of selected dioxin-like compounds on a body burden basis:  Comparison to current Toxic Equivalency Factors (TEFs). J. Toxicol. Environ. Health. 69:907-917.

Golden, B., Pyatt D.W. and Shields, P. 2006 “Formaldehyde as a Potential Human Leukemogen: An Assessment of Biologic Plausibility” Critical Reviews in Toxicology, V36:135-153.

Hays, S.M. and Pyatt, D.W. 2006 Risk Assessment for Children Exposed to Decabromodiphenyl (Oxide) Ether (Deca) in the United States.” Integrated Environmental Assessment and Management. V2 (1):2-12.

Buchanan, S., Menze, M., Hand, S., Pyatt, D.W. and Carpenter, J. 2005 “Cryopreservation of Human Hematopoietic Stem and Progenitor Cells Loaded with Trehalose: Transient Permeabilization via the ATP-Dependent P2Z Receptor Channel” Cell Preservation Technology, V3(4):212-222.

Pyatt, D.W., Hays, S. and Cushing, C.  2005 “Do Children Have Increased Susceptibility for Developing Secondary Acute Myelogenous Leukemia?” Cell Biology and Toxicology, V153-154:223-229

Aylward, L.L., Brunet, R., Starr, T., Carrier, G., Delzell, E., Cheng, H., and Beall, C.  2005.  Exposure reconstruction for the TCDD-exposed NIOSH cohort using a concentration- and age-dependent model of elimination.  Risk Anal.  25(4): 945-956.

Connor, K.C. and Aylward, L.L. .  2006.  Human response to dioxin:  Aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.  J. Toxicol. Environ. Health Part B:  Critical Reviews. 9:147-171.

Wright, P.C., Long, T.F., and Aylward, L.L.   2005.  Twenty-five years of dioxin cancer risk assessment.  Natural Resources & Environment.  19(4): 31-35.

Aylward, L.L., Lamb, J.C., and Lewis, S.  2005.  Issues in risk assessment for developmental effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and related compounds. Toxicol. Sci. 87(1): 3-10.

Zheng, T., Pyatt, D.W., Gross, S.  A. Le and Irons, R. D. 2004.  Hydroquinone Modulates GM-CSF in TF.1 cells.  Leukemia p1-9.

Buchanan, S., Gross, S., Mehmet, T., Carpenter, J. and Pyatt, D. W. 2004 “A Novel Methodology for Cell Preservation Using Non-Toxic Sugars”.  Journal of Stem Cells and Development, V13, #3, p295- 305.

Aylward L.L., Brunet R.C., Carrier G., Hays S.M., Needham L.L., Patterson D.G., Gerthoux P.M, Brambilla P. and Mocarelli P. 2004. Concentration-dependent TCDD elimination kinetics in humans: Toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy and Vienna, Austria and impact on dose estimates for the NIOSH cohort.  Journal of Exposure Analysis and Environmental Epidemiology. 15(1):51-65.

Gaylor, D.W. and Aylward, L.L. .  2004.   An evaluation of benchmark dose methodology for non-cancer continuous-data health effects in animals due to exposures to dioxin (TCDD).  Reg. Toxicol. Pharmacol 40: 9–17.

Ruby, M.V., Casteel, S.W., Evans, T.J., Fehling, K.A., Paustenbach, D.J., Landenberger, B.D., Budinsky, R.A., Giesy, J.P., and Aylward, L.L.   2004.  Rapid communication:  Background concentrations of dioxins/furans in Sprague-Dawley rats and juvenile swine. J. Toxicol. Environ. Health 67(11): 845–850.

Hays, Sean, M., Cushing, C., Leung, H-W., Pyatt, D., Holicky, K. and Paustenbach, D. 2003 “Exposure of infants and children in the U.S. to the flame retardant decabromodiphenyl oxide (DBDPO)”. Journal of Children’s Health, V1, No. (4), p449-475.

Kerzic, P., Pyatt, D.W., Zheng, T., and Irons, R.D. 2003.  "Inhibition of NF-kappa B by Hydroquinone, a Benzene Metabolite, Sensitizes Human Bone Marrow Progenitor Cells to TNF-a induced Apoptosis".  Toxicology. Vol 187/2-3 p127–137.

Aylward L., Kirman C., Cher D. and Hays S. 2003. Re: Analysis of dioxin cancer threshold.  Environmental Health Perspectives, 111: A510.

Greene J., Hays S. and Paustenbach D. 2003. Basis for a proposed reference dose (RfD) for dioxin of 110 pg/kg-day:  A weight-of-evidence evaluation of the human and animal studies.  Journal of Toxicology and Environmental Health, Part B 6: 115-159

Hays S.M. and Aylward L.L. 2003. Dioxin risks in perspective:  Past, present, and future.  Regulatory Toxicology and Pharmacology, 37: 202-217.

Aylward L.L., Hays S.M., LaKind J.S. and Ryan J.J. 2003. Rapid communication:  Partitioning of persistent lipophilic compounds, including dioxins, between human milk lipid and blood lipid:  An initial assessment.  Journal of Toxicology and Environmental Health, Part A 66(1): 1–5.

Finley B.F., Ownby D.R., and Hays S.M.  2003.  Airborne Tire Particles in the Environment:A Possible Asthma Risk from Latex Proteins?  Human and Ecological Risk Assessment 9:1505-1518.

Aylward L., Kirman C., Cher D. and Hays S. 2003. Re: Analysis of dioxin cancer threshold.  Environ. Health Perspectives, 111: A510.

Aylward L.L. and Hays S.M. 2002. Temporal trends in human TCDD body burden: Decreases over three decades and implications for exposure levels. Journal of Exposure Analysis and Environmental Epidemiology. 12: 319-328.

O’Flaherty E.J., Kerger B.D., Hays S.M. and Paustenbach D.J. 2001. A physiologically based model for the ingestion of chromium(III) and chromium(VI) by humans.  Toxicological Sciences 60: 196–213.

Pyatt, D.W., Yang, J., Zheng, T., Stillman, W.S., Le, A. Gustaphson, D. and Irons, R.D. 2001. Comparative Toxicology of Dithiocarbamates and Butadiene Metabolites in Human Lymphoid and Bone Marrow Cells.  Chemico-Biological Interactions. V135-136, p.615-625.

Baker, R.K., Pyatt, D.W., Irons, R.D., and Kroll, D.J.  2001.  "Benzene Metabolites Antagonize Etoposide Stabilized Cleavable Complexes of DNA-Topoisomerase-a".  Blood.  V98, p. 830-833

Irons, R.D., Pyatt, D.W., Gross, S. A. and Stillman, W.S.  2001.  “Hematopoietic Stem and Progenitor Cells as Targets for Biological Reactive Intermediates”.  In Press, Advances in Experimental Medicine and Biology.

Kirman C.R., Hays S.M., Kedderis G.L., Gargas M.L. and Strother D.E. 2000. Improving cancer dose-response characterization by using physiologically based pharmacokinetic modeling:  An analysis of pooled data for acrylonitrile-induced brain tumors to assess cancer potency in the rat.  Risk Analysis 20: 135–151.

Hays S.M., Elswick B.A., Blumenthal G.M., Welsch F., Conolly R.B. and Gargas M.L. 2000. Development of a physiologically based pharmacokinetic model of 2-methoxyethanol and 2methoxyacetic acid disposition in pregnant rats.  Toxicology and Applied Pharmacology 163: 67–74.

Gargas M.L., Tyler T.R., Sweeney L.M., Corley R.A., Weitz K.K., Mast T.J., Paustenbach D.J. and Hays S.M. 2000. A toxicokinetic study of inhaled ethylene glycol ether acetate and validation of a physiologically based pharmacokinetic model for rat and human.  Toxicology and Applied Pharmacology 165: 63–73.

Gargas M.L., Tyler T.R., Sweeney L.M., Corley R.A., Weitz K.K., Mast T.J. Paustenbach D.J. and Hays S.M. 2000. A toxicokinetic study of inhaled ethylene glycol monomethyl ether (2ME) and validation of a physiologically based pharmacokinetic model for the pregnant rat and human.  Toxicology and Applied Pharmacology 165: 53–62.

Williams P.R.D., Scott P.K., Hays S.M. and Paustenbach D.J. 2000. A screening-level assessment of household exposure to MTBE in California drinking water.  Soil Sediment & Groundwater:  MTBE Special Issue: 63–69.

Williams P.B., Hays S.M. and Finley B.L. 2000. Latex allergy:  Epidemic or epiphenomenon.  Source to Surgery 7: 1–4.

Irons, R.D., Pyatt, D. W., Stillman, W. S., Som, D., Claffey, D. and Ruth, J.  2000.  "Comparative Toxicity of Butadiene and it's Putative Metabolites in Human CD34+ Bone Marrow Cells. Toxicology  V150, p. 99-106.

Pyatt, D.W., Yang, J, Stillman, W.S., and Irons, R.D. 2000. Dithiocarbamates inhibit hematopoiesis Via a Copper Dependent Mechanism. Biochemical and Biophysical Research Communications. V.274, No. 2, p. 513-518.

Pyatt, D.W., Mehos, B., Yang, J. and Irons, R.D. 2000.  Effects of the Anti rheumatic Herbal Medicine, Tripterygii, on CD34+ Bone Marrow Cell Function and Survival.  Molecular Pharmacology. V.57, P. 1-7.

Pyatt, D.W., Stillman, W.S., Yang, J., Cano, L.L., and Irons, R.D. 2000.  Hydroquinone, an active metabolite of Benzene, inhibits PMA-induced activation of NF-kB in Primary Human CD19+ B Lymphocytes. Cell Biology and Toxicology, Vol. 16 (1), p.41-51.

Pyatt, D.W., Stillman, W.S., Yang, J., Zheng, T., Gross, S., and Irons, R.D. 1999.  An Essential Role for NF-kB in Human CD34+ Bone Marrow Cell Survival.  Blood.  Vol. 93, No. 10, p. 1-8.

Pyatt, D.W., Stillman, W.S. Gruntmeir, J., and Irons, R.D. 1998.  Dimethyldithiocarbamate (DMDTC) Inhibits Activation of Human CD4+ T lymphocytes.  Toxicology .  V.128, p. 83-90.

Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1998.  Hydroquinone, a reactive metabolite of Benzene, inhibits  NF-࿓kB in primary human CD4+ T lymphocytes.  Toxicology and Applied Pharmacology.  V.149, p. 178-184.

Aylward L.L., Karch N.J., Hays S.M. and Paustenbach D.J. 1998. Response to comment on a relative susceptibility of animals and humans to the cancer hazard posed by 2,3,7,8-tetrachlorodibenzo-p-dioxin using internal measures of dose.  Environmental Science and Technology 32: 551–552.

Hays S.M., Long T.F., Kirman C.R. and Gargas M.L. 1998. Potential uses of PBPK modeling to improve the regulation of exposure to toxic compounds.  Inside EPA’s Risk Policy Report 5: 37–41.

Irons, R.D., and Pyatt, D.W. 1997.  Dimethyldithiocarbamate is a Potential Confounder in Butadiene Epidemiology.  Carcinogenesis.  V. 19, No. 4, p. 539-542

Gross, S., Helm, K., Gruntmeir, J., Pyatt, D.W., Stillman, W.S., and Irons, R.D. 1997.  Characterization and phenotypic analysis of differentiating CD34+ human bone marrow cells in liquid culture.  European Journal of Haematology.  V.59, p. 318-326.

Hays S.M., Aylward L.L., Karch N.J. and Paustenbach D.J. 1997. The relative susceptibility of animals and humans to the carcinogenic hazard posed by exposure to 2,3,7,8-TCDD:  An analysis using standard and internal measures of dose.  Chemosphere 34: 1507–1522.

Verhar H.J.M., Morroni J.R., Reardon K.F., Hays S.M., Garver D.P., Carpenter R.L. and Yang R.S.H. 1997. A proposed approach to study the toxicology of complex mixtures of petroleum products:  The integrated use of QSAR, lumping analysis and PBPK/PD modeling.  Environmental Health Perspectives 105(Suppl.): 179–195.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1996.  Reactive oxygen species mediate stem cell factor synergy with GM-CSF in a sub-population of primitive hematopoietic progenitor cells. Molecular Pharmacology. V.49, p.1097-1103.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1996.  Inorganic lead activates the nuclear transcription factor, NF-kB, in primary human CD4+ T-Lymphocytes. Biochemical and Biophysical Research Communications. V.227, p.380-385.

Aylward L.L., Hays S.M., Karch N.J. and Paustenbach D.J. 1996. Relative susceptibility of animals and humans to the cancer hazard posed by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) using internal measures of dose.  Environmental Science and Technology 30: 3534–3543.

Lipiro D., Hays S.M. and Golpashin E. 1996. Evaluation of source reduction methods through modeling of batch production processes in the coatings and composite plastics industries.  Journal of the Air and Waste Management Association.

Paustenbach D.J., Hays S.M., Brien B.A., Dodge D.G. and Kerger B.D. 1996. Observation of steady-state in blood and urine following human ingestion of hexavalent chromium in drinking water.  Journal of  Toxicology and Environmental Health 49: 453–461.

Sielken R.L., Reitz R.H. and Hays S.M. 1996. Using PBPK modeling and comprehensive realism methodology for the quantitative cancer risk assessment of butadiene.  Toxicology 113: 231–237.

Aylward, L.L., Roylance, D.K., and Douglas, C.D.  1985.  A transient finite element model of pultrusion.  Polymer Process Engineering, 3(3).
 

Book Chapters:

Pyatt, D.W, 2004, Benzene and Hematopoietic Malignancies, Industrial Solvents and  Human Health, Part 1, Clinics in Occupational and Environmental Medicine, V4, No. 1,  p.529-555.

Hays S.M. and Finley B.L. 2002. Qualitative health risk assessment of natural rubber latex in consumer products. In Paustenbach D.J. Ed. Human and Ecological Risk Assessment: Theory and Practice. New York: John Wiley and Sons.

Arfsten, D.P., Aylward, L.L., and Karch, N.J.  1998.  Chromium.  In: Immunotoxicology of Environmental and Occupational Metals.  J.T. Zelikoff and P.T. Thomas, (eds.) Taylor and Francis, London.

Thomas, P.T., Aylward, L.L., and Karch, N.J.  1998.  Immunotoxicity of dioxin:  Is the TEF concept premature?  In: Chlorine and Chlorine Compounds in the Paper Industry. Victor Turoski, (ed.), Sleeping Bear Press, Chelsea, Michigan. pp. 307–314.
 

Abstracts and Presentations:

Aylward, L.L., R.A. Becker, and S.M. Hays.  2006.  Interpreting Human Biomonitoring Data in a Risk Assessment Context: Issues and Approaches.  Presented at the Society for Risk Assessment 2006 Annual Meeting, Baltimore, MD, December 2006.

Hays, S., L. Aylward, D. Pyatt, H. Leung, and R. Becker.  2007.  Interpreting human biomonitoring data in a risk assessment context: Biomonitoring equivalents.  Abstract No. 427.  Toxicologist 96(1):89.

Aylward, L. and S. M. Hays.  2007.  Interpretation of biomonitoring data for toluene: Use of PBPK modeling.  Abstract No. 781.  Toxicologist 96(1):161.

Butterworth, B.E., L.L. Aylward, and S.M. Hays. 2007.  Mechanism-based cancer risk assessment for 1, 4-dichlorobenzene.  Abstract No. 1550, Toxicologist 96(1):321.

Kirman, C., E. Crouch, L. Aylward, T. Simon, R. Budinsky, B. Landenberger, and T. Long.  2007.  Cancer potency estimate for 2,3,4,7,8-pentachlorodiobenzo(p)dioxin (4-PeCDF).  Abstract No. 1561, Toxicologist 96(1):323.

Javier, A., J.M. Panko, E.C. Shay, K.M. Unice, P.S. Price, S. Hays and L. Aylward. 2007.       Assessment of children’s exposure to toluene.  Abstract No. 1620, Toxicologist 96(1):335.

Pyatt, D., S. Hays, L. Aylward, P. Kerzic, and C. Borgert.  2007.  The role of hematotoxicity in chemically induced acute myeloid leukemia.  Abstract No. 1963, Toxicologist 96(1):405.

Budinsky, R., L. Aylward, C. Cushing, G. Fent, M. Ruby and S. Casteel.  2007.  Estimation of relative bioavailability of dioxins and furans in soil in rats and swine:  Impact of differential EROD induction on bioavailability estimates.  Abstract No. 2011, Toxicologist 96(1):415.

Golden, R. and D. Pyatt.  2007.  Can inhaled formaldehyde result in hematopoietic malignancies?  Abstract No. 1964, Toxicologist 96(1):405.

Stickney, J., M. Odin, S. Hays, and R. Dewoskin.  2007.  Development of a screening framework for data review and analysis to support the derivation of a neurodevelopmental toxicity value for ethanol.  Abstract No. 1629, Toxicologist 96(1)337.

Pyatt, D.W. and Hays, S. 2006 “Age related differences in secondary malignancies in  children: Lessons learned from the pediatric clinical experience.” Toxicological Sciences  V.97, S1, #114.

Pyatt, D.W. and Hays, S., 2005 “Biomarkers of Susceptibility” Annual Meeting Society  of Risk Analysis.

Hays, S. and Pyatt, D.W. 2005 “Interpreting Biomarkers of Exposure” Annual Meeting  Society of Risk Analysis.

Pyatt, D.W., Hays, S. Cushing, C.  2005 “Are there age related differences in Children’s Susceptibility for Developing Secondary Acute Myelogenous Leukemia?”  Toxicological Sciences V.89, S1, #258.

Paustenbach, D. J., Madl, A.K., Unice^, K., Scott^, P., Robinson, K. P. Scaramella, K.P., and Pyatt, D.W. 2005 “Exposure Reconstruction of Historical Airborne Benzene Concentrations:  Case study of a Deck Crewman on board Crude Oil and Chemical Tankers”.  Toxicological Sciences V.89, S1, #411. 

Aylward, L.L.  Concentration-dependent elimination kinetics for TCDD in humans – impact on human cancer risk assessment.  Presented at the Society for Risk Analysis Annual Meeting, Orlando, FL, December 5, 2005.

Pyatt, D.W., Hays, S. Cushing, C.  2004 “Do Children Have Increased Susceptibility for Developing Secondary Acute Myelogenous Leukemia?”  Recent Advances in Benzene Toxicity, Munich, Germany, Oct 9-12.

Proctor D., Cohen E., Leung H., Hays S.M., Barraj L. and Madl A. 2004. Exposure Assessment for Perchlorate in Drinking Water. Abstract #1754. Final Program and Abstracts.  43^rd Annual Meeting of Society of Toxicology, Baltimore, MD. March 24.

Madl A., Proctor D., Leung H., Goswami E., Hays S.M. and Cohen E. 2004. Derivation of a RfD for Perchlorate: Identifying a Critical Health Endpoint and the Most Sensitive Subpopulation. Abstract #1755. 43^rd Annual Meeting of Society of Toxicology, Baltimore, MD. March 24.

Leung H., Proctor D., Madl A., Hays S.M. and Cohen E. 2004. Scientific Rationale for the Derivation of a RfD for Perchlorate. Abstract #1756. 43^rd Annual Meeting of Society of Toxicology, Baltimore, MD. March 24.

Yost L., Greene J.F., Hays S.M., Kelsh M. and Sheehan P. 2004. Derivation of a Range of Interim Inhalation Cancer Slope Factors for TCE Using Physiologically Based Pharmacokinetic Modeling. Abstract #1762. 43^rd Annual Meeting of Society of Toxicology, Baltimore, MD. March 24.

Madl, A., Pyatt, D.W., Widner, T. E., and Paustenbach, D. J. 2004  “Airborne Benzene Concentrations Associated with Chainsaw Use during Tree Trimming Operations”.  International Society of Exposure Analysis. 

Buchanan, Sandhya, Menze, Michael, Hand, Steven C, Carpenter^, John, and Pyatt, D.W. 2004 “Permeabilization of Hematopoietic Progenitor Cells to Trehalose using P2Z Purinoreceptor-Associated Pores for the Purpose of Cryopreservation”.  Experimental Hematology, V.39, (9), #37.

Kerzic, P., Pyatt, D., Zheng, T., Le, A., and Irons, R. 2004 “Selective inhibition of I kappa kinase (IKK) by benzene metabolites”. Experimental Hematology, V.39, (9), #234

Aylward, L.L., Brunet, R., Starr, T., Delzell, E., Cheng, H. and Beall, C.  2004.  Exposure reconstruction for the TCDD-exposed NIOSH cohort using a concentration- and age-dependent model of elimination.  Organohalogen Compounds 66: 3394–3400.

Hays, Sean, M., Cushing, C., Leung, H-W., Pyatt, D., Holicky, K. and Paustenbach, D. 2003 “Exposure of infants and children in the U.S. to the flame retardant decabromodiphenyl oxide (DBDPO)”. Society of Risk Assessment, Baltimore MD.

Kerzic, P., Pyatt, D., Zheng, T., Le, A., and Irons, R. 2003 “Direct Inhibition of I Kappa Kinase Activity by Benzene Metabolites Sensitizes Bone Marrow Cells to Cytokine-Induced Apoptosis”.  Toxicological Sciences V.72, S1, #1716.

Cushing, C.A., Holicky, K., Pyatt, D.W., Staskai, D., Finley, B. L., Paustenback, D.J., Hays, S.M. 2003 “Estimated Children’s Exposure to Decabromodiphenyl Oxide in the US.” Toxicological Sciences V.72, S1, #1906.

Freed, B.M., Ouyang, Y., Yang, J., Pyatt, D.W., McCue, J.  2003 “Suppression of Inflammatory Cytokine Production by Cigarette Smoke is Mediated by Acrolein”  Toxicological Sciences V.72, S1, #841.

Aylward, L.L. TCDD elimination kinetics in adults from Seveso:  Implementation of the Carrier et al. (1995) model.  Presented at Dioxin 2003, Boston, MA, August 26, 2003.

Aylward, L.L., Carrier, G., Brunet, R.C., and Hays, S.M.  2003.  TCDD kinetics in Austrian patients:  Implementation of the Carrier et al. (1995) model.  Organohalogen Compounds 65: 238–241.

Aylward, L.L., Carrier, G., Brunet, R.C., Hays, S.M., Needham, L.L., Patterson, D.G., Jr., Gerthoux, P.M., Brambilla, P., and Mocarelli, P.  2003.  TCDD elimination kinetics in adults from Seveso:  Implementation of the Carrier et al. (1995) model.  Organohalogen Compounds 65: 199–202.

Brunet, R.C., Aylward, L.L., Carrier, G., and Hays, S.M.  2003.  TCDD elimination kinetics:  Modification of the Carrier et al. (1995) model to include an additional elimination mechanism.  Organohalogen Compounds 65: 226–229.

Aylward, L.L., Hays, S.M., Brunet, R.C., Carrier, G., and Cushing, C.A.  2003.  Impact of a concentration-dependent elimination rate for TCDD on dose estimates for the NIOSH cohort.  Organohalogen Compounds 64: 128–131.

Hays S.M. and Paustenbach D.J. 2002. Temporal trends in human TCDD body burden.  Vietnam Scientific Conference on Human Health and Environmental Effects of Agent Orange/Dioxin, March 3–6, 2002.  Ha Noi, Vietnam.

Proctor D.M., Hays S.M., Ruby M.V., Liu S., Sjong A., Goodman M. and Paustenbach D.J.  2002.  Rate of hexavalent chromium reduction by human gastric fluid.  Abstract #1700.  Final Program and Abstracts.  41st Annual Meeting of Society of Toxicology, Nashville, TN, March 17-21.

Aylward, L., Hays S.M. and Finley B.  2002.  Temporal trends in intake of dioxins from foods in the U.S. and Western Europe:  Issues with intake estimates and parallel trends in human body burden.  Organohalogen Compounds 55: 235–238.

Buchanan, S, Gross, S, Acker, J.P. Toner, M., Carpenter, J, and Pyatt, D.W. 2002 “A Novel Technique for Long-term Cryopreservation of HPC using Non-toxic Sugars.” Society of Cryobiology, 2002 Annual Meeting. 

Zheng, T, Gross, S, Pyatt, D, Kerzic, P, and Irons, R 2002 “Alterations in a GM-CSF Signaling Pathway by the Benzene Metabolite Hydroquinone” Experimental Hematology V.30, (6), #205.

Kersic, P., Pyatt, D. W., Yang, J., Zheng, T., and Irons, R. D. 2002.  “Hydroquinone inhibits NF-kB and Synergizes with TNF in the Induction of Apoptosis inCD34+ Hematopoietic Progenitor Cells.” Experimental Hematology V.30, (6), #59.

Buchanan, S Gross, S, Acker, J.P. Toner, M. Carpenter, J and Pyatt, D.W. 2002 “A Novel Technique for Long-term Cryopreservation of Hematopoietic Progenitor Cells using Intracellular Trehalose.” Experimental Hematology V.30, (6), #380.

Lowney, Y., Tsuji, J., Pyatt, D.W., Yost, L., Cushing, C., and Paustenbach, D.  2002  “Children’s Exposure to Metals from CCA Treated Wood:  Important Factors in Assessing Inadvertent Ingestion Exposures.  International Society of Exposure Analysis.

Aylward, L. and Hays, S. Humans as bio-indicators of dioxin levels:  Temporal trends.  Presented at the Society for Risk Analysis Annual Meeting, New Orleans, LA, December 11, 2002 (presented by Sean Hays).

Aylward, L.   Humans as bio-indicators of dioxin levels:  Temporal trends.  Presented at the State of the Lakes Ecosystem Conference (SOLEC), Cleveland, OH, Oct. 17, 2002.

Aylward, L., Hays, S., and Finley, B.  2002.   Dioxin exposures and risk in perspective:  Past, present and future.  Presented at Society of Toxicology Annual Meeting, Nashville, TN, March 21, 2002 (Poster presented by Brent Finley).

Hays, S. and Aylward, L.  2002.  Temporal trends in human TCDD body burden:  Decreases over three decades and implications for exposure levels.  Presented at the International Society of Exposure Analysis Annual Meeting, August 12, 2002, Vancouver, B.C., (Poster presented by S. Hays).

Fehling K.A., Bono M.A., Hays S.M. and Paustenbach D.J. 2001.  Identification of a Proposition 65 no significant risk level for coal tar.  Abstract #2093.  Final Program and Abstracts.  40th Annual Meeting of Society of Toxicology, San Francisco, CA, March 25-29.

Hays S.M. and Aylward L.L.  2001.  Temporal trends in body-burden suggest that dioxin exposures in the general population have declined significantly.  Organohalogen Compounds 52: 214–216.

Hays S.M., Aylward L.L., Finley B. and Paustenbach D.J.  2001.  Implementing a cancer risk assessment for dioxin using a margin of exposure approach and an internal measure of dose. Organohalogen Compounds 53: 225–228.

Gross, S. A., Pyatt, D. W. and Irons, R. D. 2001 Altered phosphorylation of PU.1 by the benzene metabolite Hydroquinone. Experimental Hematology V. 22 (5), #278.

Ouyang, Y., Zheng, J., Yang, Y., Pyatt, D.W., Irons, R.D. and Freed, B.M.  2001  “Suppression of Human Cytokine Expression by the Vapor from Cigarette Smoke Extracts is Mediated by Decreased NF-kB and AP.1.  The Toxicologist  V, V60, (1), #131.

Kirman C., Aylward L.L., Karch N.J., Paustenbach D.J., Finley B. and Hays S.M.  2000.  Is dioxin a threshold carcinogen?  Quantitative analysis of the epidemiological data using internal dose and Monte Carlo methods.  Organohalogen Compounds 48: 219–222.

Lowney Y., Deubner D., Hays S.M., Chapman P., Kerger B., Shields W. and Paustenbach D.J.  2000.  Biomonitoring for beryllium:  Experience with a U.S. work force.  Abstract 1454. 39th Annual Meeting of the Society of Toxicology, Philadelphia, PA.

Hays S.M., Butcher M., Hook G., Lowney Y., Kirman C. and Paustenbach D.J.  2000.  Probabilistic distributions for PBPK model parameters.  Toxicologist 54: 90.

Kirman C.R., Long T.F., Leber A.P., Hays S.M. and Gargas M.L.  2000.  Using pharmacokinetic modeling and Monte Carlo methods to improve estimated bioconcentration factors and half-lives for substituted diphenyl-p-phenylene diamines in carp.  Toxicologist 54: 58.

Finley B.L., Cher D.J. and Hays S.M.  2000.  Natural rubber latex:  A critical review.  Toxicologist 54: 247.

Lowney Y.L., Deubner D., Hays S.M., Chapman P., Kerger B., Shields W. and Paustenbach D.J. 2000.  Biomonitoring for beryllium:  Experience with a U.S. workforce.  Toxicologist 54: 310.

Gross, S.A., Pyatt, D.W., Shpall, E.J., Bearman, S., and McNiece, I.  2000  "Ex vivo expansion of CD3+ cells from umbilical cord blood for use as donor lymphocyte infusions in relapse patients". Experimental Hematology, 28, p89 #185.

Pyatt, D.W., Stillman, W.S., Yang, J. Le, A. and Irons, R.D. 2000  "Hematotoxicity of Dithiocarbamates on CD34+ Human Bone Marrow Cells".  The Toxicologist  V54, 1-S, #.1654.

Pyatt, D.W., Stillman, W.S., Yang, J. Le, A. and Irons, R.D. 2000  "Hematotoxicity of the Chinese Herbal Medicine, Tripterygium Wilfordii  Hook f in CD34+ Human Bone Marrow Cells".  The Toxicologist  V54, 1-S, #. 1655

Baker, R., Pyatt, D.W., Irons, R.D., and Kroll, D.  2000  "Catalytic Inhibition of Topoisomerase II alpha by Benzene Metabolites".  The Toxicologist  V54, 1-S, #.1656.

Hays S.M., Finley B.L. and Cher D.J.  1999.  Natural rubber latex:  A critical review.  Final Program and Abstracts.  Society for Risk Analysis Annual Meeting and Exposition, Atlanta, GA.

Gargas M.L., Kirman C.R., Hays S.M. and Voytek P.  1999.  Using physiologically based pharmacokinetic modeling to minimize animal testing and associated costs under USEPA’s Hazardous Air Pollutants Test Rule.  Toxicological Sciences 48 (Supplement:  The Toxicologist): 141.

Hays S.M., Tyler T.R., Snellings W.M., Weitz K.K., Corley R.A., Kirman C.R. and Gargas M.L.  1999.  Physiologically based pharmacokinetic (PBPK) modeling of ethlyene glycol ethers and acetates in pregnant rats.  Toxicological Sciences 48 (Supplement:  The Toxicologist): 142.

Rish W., Kirman C.R., Hays S.M., Gargas M.L., Andersen M.E., Reitz R.H., Guengerich F.P., Green T., McConnell E.E., Buckpit A., Voytek P. and Dugard P.H.  1999.  Developing a physiologically based pharmacokinetic model to describe methylene chloride kinetics at the subcellular level.  Toxicological Sciences 48 (Supplement: The Toxicologist): 143.

Gross, S.A., Shpall, E.J., Bearman, S., Pyatt, D.W., and McNiece, I.  1999  "Ex vivo culture of cord blood T cells for use as donor lymphocyte infusions in relapsed patients".  Blood  V94, No. 10, Supp 1, p.4695.

Gross, S.A., Shpall, E.J., Bearman, S., Pyatt, D.W., and McNiece, I.  1999  "Ex vivo expansion of cord blood T cells for use as donor lymphocyte infusions in relapsed CML patients.'Division of Medical Oncology Poster Session, School of Medicine, University of Colorado Health Sciences Center, Denver, CO.

Pyatt, D.W., Yang, J., Zheng, J., Stillman, W.S., and Irons, R.D.  1999  "Inhibition of NF-kB in Primary Human CD19+ B Lymphocytes by Hydroquinone."  The Toxicologist  V48, 1-S, P.824.

Gross, S.A., Pyatt, D.W., Yang, J., Zheng, J., Stillman, W.S., and Irons, R.D.  1999  "Hydroquinone Alters the Phosphorylation State of the Transcription Factor PU.1 in Human CD34+ Hematopoietic Progenitor Cells."  The Toxicologist  V.48, 1-S, p. 172

Gargas M.L., Kirman C.R., Dugard P. and Hays S.M.  1998.  Using expert elicitation to develop a quantitative risk assessment for methylene chloride.  Final Program and Abstracts.  Society for Risk Analysis Annual Meeting and Exposition, Phoenix, AZ.

Kirman C.R., Hays S.M., Aylward L., Karch N.J. and Paustenbach D.J.  1998.  Is TCDD a threshold carcinogen?  A quantitative analysis of the epidemiological data.  Abstract 1.02.  Final Program and Abstracts.  Society for Risk Analysis Annual Meeting and Exposition, Phoenix, AZ.

Pyatt, D.W., Stillman, W.S., Yang, J. and Irons, R.D. 1998  "A Potential Role for NF-kB in Human CD34+ Bone Marrow Cell Function and Survival."  International Society of Experimental Hematology , Experimental Hematology  V. 26, N.8, p.735.

Gross, S.A., Pyatt, D.W., Yang, J., Stillman, W.S., and Irons, R.D.  1998  "Hydroquinone Alters DNA Binding Activity of the Transcription Factor PU.1 in Human CD34+ Hematopoietic Progenitor Cells."  The Toxicologist  V. 42,1-S, p.269.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1998  "Hydroquinone Inhibits NF-kB in Primary Human CD4+ T Lymphocytes."  The Toxicologist  V. 42,1-S, p. 270.

Andersen M.E., Gargas M.L., Hays S.M., Clewell H.J. and Paustenbach D.J.  1997.  Estimating minimally effective inducing doses (ED01s) of TCDD in livers of rats and humans using physiologically based pharmacokinetics modeling.  Organohalogen Compounds 34:  311–316.

Aylward L.L., Hays S.M., Czernec J., Brien B., Paustenbach D.J. and Karch N.J.  1997.  Relative doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) using alternative dosimetrics:  comparison of the NIOSH and ranch hand populations.  Organohalogen Compounds 34: 6–9.

Hays S.M., Aylward L.L., Mocarelli P., Needham L.L., Brambilla P., Gerthoux P.M., Patterson D.G., Czernec J., Paustenbach D.J. and Karch N.J.  1997.  Comparative dose-response of the NIOSH and Seveso populations to the carcinogenic hazard of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) using alternative dosimetrics.  Organohalogen Compounds 34: 305–310.

Paustenbach D.J., Hays S.M., El-Sururi S., Underwood P. and Ku R. 1997. Comparing the predicted uptake of TCDD based on exposure calculations with the actual uptake: A case study of residents of Times Beach, MO. Organohalogen Compounds 34: 25-31.

Hays S.M., Aylward L.L., Karch N.J. and Paustenbach D.J.  1997.  The relative susceptibility of animals and humans to the carcinogenic hazard posed by exposure to 2,3,7,8-TCDD:  an analysis using standard and internal measures of dose.  Chemosphere 34: 1507–1522.

Verhar H.J.M., Morroni J.R., Reardon K.F., Hays S.M., Garver D.P., Carpenter R.L. and Yang Y.S.H.  1997.  A proposed approach to study the toxicology of complex mixtures of petroleum products:  the integrated use of QSAR, lumping analysis and PBPK/PD modeling.  Environmental Health Perspectives 105: 179–195.

Irons, R.D., Pyatt, D.W., Gross, S., Gruntmeir, J. and Stillman, W.S.  1997  "Characterization of the Effects of Hematotoxic Agents on Differentiating CD34+ Human Bone Marrow Cells in Liquid Culture."  First International Symposium on Hematotoxicology, Palazzo dei Congressi, Lugano, Switzerland.

Pyatt, D.W., Stillman, W.S., Zheng J-H.,  and Irons, R.D.  1997  "Activation of NF-kB in Primary Human CD4+ Lymphocytes by Lead Acetate." The Toxicologist  V.36, p.262.

Luckey, S.W., Pyatt, D.W.,  and Irons, R.D.  1997 "Nuclear Factor-kB Activation and Regulation of IL-2 Receptor Alpha Chain Expression by Nickel Chloride in Primary Human CD4+ Lymphocytes." The Toxicologist  V.36, p.264.

Aylward L.L., Hays S.M., Karch N.J. and Paustenbach D.J.  1996.  Relative susceptibility of animals and humans to the cancer hazard posed by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) using internal measures of dose.  Environmental Science and Technology 30:3534–3543.

Lipiro D., Hays S.M. and Golpashin E.  1996.  Evaluation of source reduction methods through modeling of batch production processes in the coatings and composite plastics industries.  Journal of the Air and Waste Management Association

Paustenbach D.J., Hays S.M., Brien B.A., Dodge D.G. and Kerger B.D.  1996.  Observation of steady-state in blood and urine following human ingestion of hexavalent chromium in drinking water.  Journal of Toxicology and Environmental Health 49: 453–461.

Sielken R.L., Reitz R.H. and Hays S.M.  1996.  Using PBPK modeling and comprehensive realism methodology for the quantitative cancer risk assessment of butadiene.  Toxicology 113: 231–237.

Hays S.M., Scott P., Fehling K., Proctor D. and Gargas M.L.  1996.  A detailed comparison of the various models used to predict blood lead concentrations for a given exposure scenario.  Fundamental and Applied Toxicology 30(Supplement: The Toxicologist):248.

Paustenbach D.J., Hays S.M., Kerger B.D. and Finley B.  1996.  An analysis of inter-individual variability in uptake and elimination of chromium from human volunteers.  Fundamental and Applied Toxicology 30(Supplement: The Toxicologist): 35.

Reardon K.F., Hays S.M. and Yang Y.S.H.  1996.  The modeling of diffusion-limited compounds in physiologically-based pharmacokinetic (PBPK) models.  Fundamental and Applied Toxicology 30(Supplement: The Toxicologist): 249.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1996  "Antioxidants selectively suppress stem cell factor synergy in murine hematopoietic progenitor cells (HPC)." The Toxicologist  V.30, p.133.

Pyatt, D.W., Stillman, W.S. and Irons, R.D.  1995  "Inorganic Lead Mimics Stem Cell Factor is a Select Subpopulation of Murine Hematopoietic Cells".  Graduate Student Research Forum, University of Colorado Health Sciences Center, Denver, CO.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1995  "Hematopoietic Alterations Induced By Lead in Bone Marrow Derived Progenitor Cells May Be Mediated By Reactive Oxygen Intermediates".  The Toxicologist  V.15, p.221.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1995  "Reactive oxygen species are required for Stem Cell Factor and Interleukin-3 mediated signal transduction in a subpopulation of primitive hematopoietic progenitor cells in C57BL/6 mice."  Research Forum, University of Colorado School of Pharmacy, Denver, CO.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1995  "Reactive oxygen species mediate stem cell factor synergy in murine hematopoietic progenitor cells."  Mountain West Society of Toxicology, Ft. Collins, CO.

Hays S.M., Reardon K.F and Yang Y.S.H.  1995.  An a priori physiologically-based pharmacokinetic/pharmacodynamic model of benzo(a)pyrene.  Toxicologist 15: 270.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1994 "Effects of In Vitro  Lead Acetate Pretreatment on Colony Forming Ability of Murine  Bone Marrow Cells".  Experimental Hematology  V.22, p.261.

Pyatt, D.W., Stillman, W.S., and Irons, R.D.  1994 "Lead Induced Alterations in Growth Factor Response in Bone Marrow Derived Stem Cells".  Mountain West Society of Toxicology, Albuquerque, NM.

Heinrich M.D., Hays S.M., Ramsdell H.S., Tessari J.D. and Yang Y.S.H.  1993.  A physiologically based pharmacokinetic model for the interaction of vinyl chloride and ethanol.  Toxicologist 14: 41.

Pirages, S.W., Johnston, J.E., and Aylward, L.L. .  1991.  Risk assessment:  It’s not really black magic.  Proceedings of the Canadian Waste Management Conference, Toronto, Ontario. October 29–November 1, 1991.